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Shuai,
R3 is 1G ohm. IIB typical is 30pA. That is a 30mV DC voltage on R3.
VIO output error of U2A could be as high as 6mV
VIO ouput error of U2B could be as high as 6mV * 2 = 12mV.
Therefore VIO induced error could be as high as +/-18mV and IIB error of -30mV typical.