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INT- TPS43331 EN and I2C control

Hi, team,

For TPS43331, based on spec page 28-30, with EN high to make the IC at active mode, as Buck2 is controled by I2C, is there any power on or power down sequence requirements for 'EN' pin and I2C programing? Or they are just toltally independent to use as EN also ontrols BUCK1 and other rails?

Thanks.