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TAS6424M-Q1: 3.3V will be applied on the I2C pin when TAS6424 is off. Is that problem?

Part Number: TAS6424M-Q1
Other Parts Discussed in Thread: TAS6424

Application is using TAS6424M-Q1.

The customer will use the other power line for the I2C pull-up because it need to communicate with I2C when TAS6424 is off.

The question is:

3.3V will be applied on the I2C pin of TAS6424 when TAS6424 power is off. Would it have problem?