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TLC7135: Floating Power Source + Earth Ground Current Sense?

Part Number: TLC7135

I am designing a 0-3A power supply with a possibly earth ground connection.  I would like to keep the supply connected to earth ground if possible.  I am using the TLC7135 differential input A/D digital display driver and a sense resistor in a panel meter with a low-side current return ( I'm not calling it ground for sake of clarity) to measure the supply's current. The power source for this supply is floating and thus has no particular potential to earth ground.  I could adapt the panel meter to measure the high-side current but a low-side current sense would be much easier.  Ultimately my question is: Can I connect  the power supply's output to earth ground and still have the panel meter measure the return current to the floating power source accurately and reliably?