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SN65DP159: DDC / I2C Conditioner?

Part Number: SN65DP159
Other Parts Discussed in Thread: SN75DP159

What is the likelihood that I need an DDC/I2C conditioner with my SN65DP159?  

I've been trying to resolve an issue where one of my two HDMI 2.0 ports has not been successful at transmitting HDCP 2.2 keys.  The two ports use the SN65DP159; identical components except the interface connector and the routing layers on the board.  The bad HDMI port is able to output clear 4K video but it is consistently failing to recognize HDCP 2.2. 

I believe the DDC lines are giving me problems... I've played with the pullups and have gotten them tuned in enough output 4K consistently, whereas before the video would switch between 1920 x 1080 and 4K. 

Tips?