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MAX3221 Asynchronous communication controller

Other Parts Discussed in Thread: MAX3221

Hello TI team - I have a HID USB/I2C device that I want to try & use this MAX3221 IC as a UART interface to a PC.

The datasheet states that it is a asynchronous communication controller, but does not show any reference schematic/design.

Is there a way take my USB or I2C data lines and tie them into the input of the MAX3221 IC and make this work?

I searched the forums, but did not see any mention about this.

Thank you