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TCA9548A: How should I protect an IC? when I do not use the slave side including an IC?

Part Number: TCA9548A

Hi all

I have some questions.
1, If I don't use many slave side.(maybe one or two ch or many TCA9548A)
no I2C pull up resistors and slave any divice.
If I may let an TCA9548A damage, how should I cope?
2, Whether when I decide the supply voltage on TCA9548A, I can be careful?
(e.g., you obey the minimum voltage of the slave side or I obey the master side?)
Thank you