I'd like to understand how exactly does the interrupt self-clear on the input change. I.e., what is meant by "resetting the interrupt circuit is achieved when data on the port is changed to the original setting". For one thing, there is no "data" on the port - there is a voltage level. But furthermore, what exactly is the "original setting"? The description is similar in the TC6416A datasheet, so I presume the question applies to that as well.
Experimentally, looking on the IO Expander EVM (http://www.ti.com/tool/IO-EXPANDER-EVM