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SN74AVC8T245: Non-Working new board.

Part Number: SN74AVC8T245

I have an application with a 1.8V to 2.5V single direction translation. Here is a portion of the schematic below. 1.8V is on and correct, 2.5V is on and correct. I have toggling (10MHZ rate) signals at A side and B side is low and unchanging.

PCB seems correct. Thermal pad is connected to GND which seems correct. I am stumped.