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OPA454: High voltage amplifier circuit

Part Number: OPA454
Other Parts Discussed in Thread: OPA462, OPA828


I need to design a high voltage amplifier.

Input: -3...+12V; Output -48...+192V (gain 16)

In the OPA454 datasheet there is an application Figure 67 "output voltage boost circuit" which can expand the output voltage over the supply voltage of each single Opamp.

But this design is still not enough for my needed output voltage range (especially when the output voltages are not symmetrical to ground).

Is there another known design which can handle the needed output voltage range? Maybe additional stages of this output voltage boost circuit?

Thanks a lot in advance!