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Precision amplifier for DC amplifier

Other Parts Discussed in Thread: OP07, TLV2470, TLV333, OPA396

I am looking for a precision amplifier that can support the following conditions:


Vin: 5mV – 10mV (DC Voltage)

Single supply of 3.3V.

Vout: ~0.5V.

The voltage ripple (p-p 250uV) will be in 60Hz.

Cheap and small.


This gpamp is intended to a disposable medical device and we are looking to have 100ku/year starting 2023.


I found out these two:





What is you opinion? Do you have a better recommendation?

  • Hi Ohad,

    can you tell more about your application? Can you show a schematic?

    You say the input voltage is 5...10mV and the output voltage 0.5V. Do you mean the circuit has a DC gain of 0.5V / 5mV = 100?

    What do you mean by the 60Hz voltage ripple? Is a 250µVpp 60Hz ripple superimposed to the DC input signal? Shall it also be amplified? Or shall it be suppressed? Or shall the circuit give a noise lower than 250µVpp at 60Hz at the output?


  • Hey Ohad,

    Additionally, what offset voltage are you comfortable with? If your gain is 100, your offset voltage can end up making up a substantial portion of your signal.

    If you need something more precise we can move this inquiry to the precision amplifiers team.


  • As you said, the circuit should have a DC gain of A=100 (appr.)
    The DC voltage before the amplifying will be with 0.25mV ripple p-p and the ripple will be in 60Hz (AC on DC).
    The ripple should be amplifying as less as possible.
  • Ohad,

    I think I would recommend a precision device, I will reassign your thread to the precision amplifiers team who can help you in finding an amplifier.


  • Hi Ohad,

    The OP07 is a good, low-cost amplifier, but does have limited input and output range capability (input common mode needs to be 2 V higher than Vcc-).  Depending on the input common-mode voltage, it may not work.  Typically, for operation at 3.3 V, a wider common mode input range is required, however this depends on the circuit configuration.

    The TLV2470 has higher offset voltages (2.2 mV/1.6 mV), this would yield substantial error with a 5 mV signal.

    In order to maintain < 1% error for an input signal of 5 mV, I would recommend an amplifier with VOS < 50 uV, and rail-to-rail inputs.  A couple of devices that would be a good fit are TLV333 and OPA396.  The TLV333 is a chopper-stabilized amplifier, which yields excellent offset and drift, but may show some noise "spikes" at the chopping frequency if it is used with high impedances (> 100 kOhm) for the input signal and feedback.  The OPA396 is a linear amp., meaning there is no switching occurring internally in the amp., however offset and drift is not as low.  The TLV387 is also a lower-cost chopper-stabilized amplifier with wider bandwidth than TLV333.  The OPA397 will offer a higher bandwidth than OPA396, for a good price point at this performance level.

    I hope this helps narrow the selection.


  • Many thanks for the thorough answer! 
    Helped a lot