Hi Alikaan,
The OPA2388 can withstand up to ±10mA at the inverting and non-inverting terminals during a temporary fault condition.
Since the device is configured in a difference amplifier configuration with input series resistors R43, R49 of 10kΩ, in the event of exposure to ~ ±100V during a fault, the current through the inputs of the op-amp will be limited to ±100V/10kΩ = 10mA. Hence, the difference amplifier configuration can withstand up to 100V at the n nodes IA_R_SENSE_N and IA_R_SENSE_P with respect to the OPA388 GND.
In your application, if you foresee that the device will be exposed to an even larger voltage exceeding ~100V at the n nodes IA_R_SENSE_N and IA_R_SENSE_P inputs of the difference amplifier, then in this case, you will need to add external clamps, using Schottky diodes.
Nevertheless, to design the clamp the user needs to define the maximum over-voltage condition to properly design the external clamp.
Please review the TI Precision Lab Session explaining overstress or EOS protection:
https://www.ti.com/video/series/precision-labs/ti-precision-labs-op-amps.html
To find the session on EOS protection, look into "Topics" and browse the bottom of the page, you will find 4-sessions on op-amp:
Here is also a short article that discusses the op-amp input protection using Schottky diodes protecting an op-amp.
Let us know if you have any questions,
Best Regards,
Luis
