HI Alex,
The PGA281 is a fully-differential input and fully-differential output device.
Single-Ended Input Operation with the PGA281:
The device can certainly be used with single-ended inputs without issues by grounding the input terminal of the PGA281. Please note that the PGA281 input stage will require ±bipolar positive and negative input stage supplies. Both the PGA281 inputs require a headroom of 2.5V away from the VSP and VSN input stage supplies, hence you will require a negative supply VSN << -2.5V supply when connecting INN negative input to GND:
Single-Ended Output Operation with the PGA281:
The PGA281 is normally intended for fully-differential output operation. However, it is possible to use the device in single-ended output operation, but there will be a trade-off in accuracy of the device, since the output will now include the offset and drift errors of the VOCM amplifier. There will be also a reduction in the gain by a factor of 1/2.
The PGA281 may be used as a single-ended output by leaving one of the differential outputs unconnected. The output swing of both VOP and VON outputs must still be considered even though only one output pin is used. Keep in mind that the gain for single-ended output is half the gain for differential output, meaning that the maximum gain setting at 88V/V instead of the 176V/V specified for differential output. The VOCM pin needs to be driven to half differential voltage of the VOP/VON supplies. See PGA281 data sheet explanation below.
We also offer a new Programmable Gain Amplifier device, the PGA849 which offers single-ended output offering binary attenuations and gains of 1/8, 1/4, 1/2, 1, 2, 4, 8, and 16V/V that may be of interest. Although the PGA849 spec is not equivalent to the PGA281, it offers single-ended outputs and a higher bandwidth.
Please see below.
https://www.ti.com/product/PGA849
PGA849
Thank you and Kind Regards,
Luis
