PGA281: Bias supply

Hello Ryker, 

Yes the VOCM and VO-N can be connected to 0V (GND) as long as the datasheet is not violated. 

Here are the conditions for VOCM: 

For ideal output conditions I recommend to make VOCM mid supply between VSOP & VSON. 

Since VO-N will be connected to ground, the differential output will be turn single-ended. 

Here is an example from the datasheet: 

What power supplies and expected input voltage/frequencies does the customer have? If single-ended output is needed, the newly released PGA849 might be a better fit (depending on gain needs). 

All the best,
Carolina