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How should .WAV data be presented to converter?

Hi,

For sound data recorded in .WAV format, after the header there will all be raw actual data. There storage format is signed. For example, if data depth is 16-bit, the positive value can get up to 2^15-1, and the negative value can get down to -2^15.

Should these data be presented to the converter in its raw format, or does it need any transformation? In addition, is there any MSB/LSB consideration (datasheets say all formats should be MSB first)?

 

Paul