The ADS4149 datasheet describes the HI PERD MODE 2 bit as:
Bit[0] HI PERF MODE 2: High performance mode 2
This bit is recommended for high input signal frequencies greater than 230MHz.
0 = Default performance after reset
1 = For best performance with high-frequency input signals, set the HIGH PERF MODE 2 bit
What is the exact difference between the default and best performance regarding the high frequency input signals?
It’s not even 100% clear if the “input signal frequencies greater than 230MHz” refers to analog bandwidth or sample rate.