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Noise problem in ADS1294R

Other Parts Discussed in Thread: ADS1294R

I am using ADS1294R for ECG signal acquisition. I have designed my own schematic for the same and my development is almost in the final stage. Initially i had set a gain of 6 for the ADS based on my calculations and requirements. Later when i was doing the clinical trials, i had to decrease the gain because of the high DC offset while connecting to the patients. My issue is the increase in noise level when iam reducing the gain.I have implemented the RLD and all other settings are as per datasheet. What can i do to improve the noise performance?