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ADS7142: Inconsistent ADC readings across modes.

Part Number: ADS7142

I've just received the BOOSTXL-ADS7142 eval platform and have noticed that the ADC readings are different when run in autonomous mode and i2c mode.

eg. Applying a 2V input on CH0 in i2C mode gives an  ADC reading of 2525 but when switching to autonomous mode the ADC value is 2458  - a difference of about 50mV.

Is there any explanation why this be?