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ADS1299-6: Large 50Hz power-line noises when recording ECG with ADS1299

Part Number: ADS1299-6
Other Parts Discussed in Thread: ADS1299, ADS1298

Hello,

I am facing here the same problem when recording ECG with the ADS1299-6

I used channel IN1P, IN1N, and BIAS_DRV to measure ECG using ADS1299. I had set SRB1 on  and SRB2 to OFF, and included only channel 1 for bias generation with PGA gain =  2, But there were large amplitude of 50Hz noises and its harmonics (like 150Hz, 250Hz, etc), which was so large that it was impossible to observe the ECG signal. how can i reject the noise generated?

 Any suggestions? Thanks in advance.