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DS160PR412: Support of 2 independent PCIe Links ?

Part Number: DS160PR412
Other Parts Discussed in Thread: DS160PR421

In our PCIe Gen4 application, we want to use the DS160PR412 and DS160PR421.

Is it possible to use 2 lanes of the chip for one PCIe Link and  the remaining 2 lanes for a different independent PCIe link ?

So for example with 1x DS160PR412  and 1x DS160PR421, could we have

PCIe link #1: Gen4 x2(2 lanes)
PCIe link #2: Gen2 x2(2 lanes)

If yes, do we need to consider specific points, e.g. will the RX_Detect work ?

Thank you for your support

Michael