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ESD401: ESD401

Part Number: ESD401
Other Parts Discussed in Thread: TPD1E04U04

Dear Sir 

I'm not  expert in ESD protection line, I need to protect the I/O line, analog input, usb line  and keypad line 
on my items and I would like what do you suggest me in order to your items. 
For me is very important to protect expecially the keypad and I/O line.
My system work with 3.3V power supply 
.
I would like what do you suggest, monodirectional or bidirectional ESD item on this line? 
and the must be connect form I/O to Ground ?
I think I will use the single chanel like ESD401
but I'm not sure if is better to use bidirectional or monodirectional item. 
looking forward to recieving your  reply .
Best Regards 
Luigi