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Part Number: TUSB8041EVM
Other Parts Discussed in Thread: TUSB8041

Evaluation board for  TUSB8041: Ports 1&2 failed for "device descriptor request failed" and Ports 3&4 functional. Note that SW1 and SW2 all are set to default (as shipped) which is OFF positions. Same USB sticks functions at ports 3 &4 and multiple computers w/o the TUS8041EVM boards. 

Have gone thru the steps of unistalling devices 1&2, checking for new drivers, chkdsk/reboot/cclean etc/,  turn on fast startup, changing USB selective suspend setting, Will all these steps , problem still persists for downstream ports 1 &2.