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SN74LVC1T45-Q1: Capacitance on VCCA and back feed

Part Number: SN74LVC1T45-Q1

Hi,
We added a Zener circuit for on VCCA for overvoltage protect as below.
Could you please help to check if the capacitance of C4324 enough for this change?
Moreover, is there any expectable issue about back feed for this change?
(LP_VDDIO=3.3V)


Thank you and best regards,
Diamond