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BQ25887: BQ25887 ADC measurement

Part Number: BQ25887


My name is Babu, 

In the datasheet that have been provided ,there is no details of reference voltage of 16 bit ADC. Can you tell me the reference working voltage of ADC?

In the register map section for REG17, it has mentioned "Sign bit: overall results reported in two's complement". Can you tell me what is the exact information that you want to convey here?