Other Parts Discussed in Thread: TPS23523, LM5068, LM5067
Can TPS2660 be used to protect negative voltage rails ?
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TPS2660 cannot be used on negative voltage rail. Right now, there is no eFuse from the existing portfolio to support negative voltage rails. Please consider hot-swap controllers LM5068, LM5067 for low power designs (<100W) and TPS23523 for higher power designs.
Additional resources:
To understand the advantages of TPS23523 over traditional hot-swaps LM5067 in high power designs, please refer application note Protecting Radio, Baseband and Active Antenna Systems with TPS2352x Hot Swaps