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TUSB542: EVM hole and frame

Part Number: TUSB542

Hi,

Are the frames (red frames), 4 large holes (red frames), and 2 small holes described in Datasheet P22, 10.2 Layout Example required to create the board?

I would like to know if it is really necessary because EVM has same frames and holes.

Also, if it is required, could you tell me what it is used for?

Best Regards,

Nishie