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BUF22821: why did buf22821 back to default (avdd/2) value?

Part Number: BUF22821

Hi, 

I don't know that how did buf22821 back to avdd/2 ? 

First, our system initialized buf22821 to achieve our target for each of channels. few minutes later, all channels backed to default value(avdd/2).

I found reason that it is back to avdd/2 since signal of I2C was too duty to effect. So that, could I know how I2C can let it back to avdd/2 ?

  

Regards,

Hung Lin, Hsu