Other Parts Discussed in Thread: TMP441, TMP442, TMP423, TMP422
Please suggest TMP421AIDCNR I2C Remote and Local Temp Sensor SOT23-8 "p2p" 2nd source
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If both of your TMP421's address pins were grounded, you could drop-in a TMP422 or TMP442. If your remote junction's return (DXN) is grounded and TMP421's A0 is grounded, you could use a TMP423. You could use the automotive grade (Q1) of any of these products.