SN74CB3Q3257: Is it possible to control the 4 channels independently

Timothy,

It looks like you may have added some images that didn't go through.

The SN74CB3Q3257 switches the entire bus as described in the datasheet in section 8.4

If you're looking for a 4 channel 2:1 switch that has individual switch channel selection have you looked into the TMUX1134? 

Hope this helps,
Rami