On a Win7-64 machine here. I just installed PSPICE-TI and activated it and played around with it for a bit. Then I got back to real work and fired up emacs for some VHDL editing and I noticed that all of my vhdl-mode customizations were missing. I started to fix that and when I saved my options, I noticed that emacs was saving them to C:\SPB_Data\.emacs instead of the standard C:\Users\myname\.emacs.
After some more digging I noticed that the PSPICE install created an environment variable called HOME which points to C:\SPB_Data\! And that breaks anything that looks for such an environment variable.
Thanks a lot for that bug.
I deleted the environment variable. I don't know what this will affect.