Would these devices be footprint compatible?
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The CC2642R1 and CC2642R-Q1 are indeed pin-to-pin/footprint compatible.
RGZ = 48-pin VQFN (Very Thin Quad Flatpack No-Lead)
RTC = 48-pin VQFN (Very Thin Quad Flatpack)
Section 8.8, 8.9, and 8.12 of the Datasheet shows the thermal, BLE, and temp sensor characteristic differences between the RTC and RGZ packages.