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CC1312R: VCC=0V and GPIO=3.3V

Part Number: CC1312R
Other Parts Discussed in Thread: , SN74AXC4T245, SN74AXC1T45

Hello,
customer ask if this would be a problem if VDD is 0V (non-operating) and GPIO (UART_RX) = 3.3V? I read in chapter 13.5 "Unused I/O Pins" that a small leakage can flow. Can this leakage power the CPU?

What about VDD=1.8V-3.3V and GPIO (UART_RX) = 3.3V? Can here also a leakage current flow?

Regards, Holger