I know this is not possible with the current version of PurePath Wireless Configurator, but I'm sure it could be accomplished in software. What I'd like to see is Autonomous mic base station prior to USB enumeration and USB mic soundcard afterwards.
Looking at a pair of images generated for these roles, there appears to be substantial overlap. I can't see it being too difficult to enable I2S output prior to enumeration. Autonomous base station seems rather trivial and a subset of USB mic soundcard as the PLL can be kept fixed rather than having to adapt to USB SOF rate. In fact I don't see the need to synchronize to SOF even in USB mode in case of mic application - the easiest solution would be asynchronous IN endpoint and fixed audio PLL settings.
A crude workaround for this scenario would be to re-flash the CC85x1 every time the device role changes, but apart from it being decidedly non-elegant, it seems one would quickly run into the stated maximum 1000 flash erase cycle limit.
Could some good soul at Ti/CC customize the firmware for us?