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TPA3251: Drive a 4800Ohm 69V 1W speaker by use a transfromer problem

Part Number: TPA3251

Dear expert:

    Customer want use Amplifer to drive a ultral high impedance speaker

1. Can TPA3251 use with transformer to drive the 4800Ohm 69V 1W speaker?

2. From our test we find the high volume sound will be missing, what is the reason, how to resolve it? Thanks.

Robin