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ADS1259 hardware interfacing solution needed

Other Parts Discussed in Thread: ADS1259, PGA280, THS4521

Dear Sir,

I would like to use ADS1259 for my application, my analog input range is from +2.5V to -2.5V dc. With dual ±2.5V analog power supplies and +5V of digital power supply. So I have the folowing doubt about hardwre circuit

1) If i use the internal 2.5 V reference, then external reference of -2.5 V is also required for the above analog input range ?

2) As I am not using the PGA280 , so at  which potential SYNCOUT Pin should be tied. And what should be the resistor value?

3) I am planning to use the THS4521 as a fully differential amplifier, so the REFOUT pin of the ADS1259 can be connected to VCOM pin of THS4521 ? 

Thanks & Regards

Sameer R