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Hi Marien,
The ADS1251 could very well be functional for some supply ranges outside the 4.75V to 5.25V range. However, the device is designed around a 5V supply and this is where you would expect the best performance. I don't have any characterization data outside of that supply range to be able to tell you with certainty what happens with the chip. I would expect the overall performance to degrade as the supply voltage decreases, up until a point where the device fails functionally.
Operating at a lower supply voltage runs the risk of lower end-product yields. We don't test and screen devices at that operating condition; therefore, some devices may work better at this supply voltage than others. Also, testing at hot or cold temperatures can provide different results.
We do have other ADC's that allow for lower supply voltages, but none that would have the same package and pin-out as the ADS1251.
Regards,
Chris