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Using ADS1293 in custom circuits without the use of Evaluation Module

Other Parts Discussed in Thread: ADS1293, CC2541

I am working on a wireless ECG application and I have got Free samples from TI. This is my first attempt and I am totally novice. I am clueless about how to use the AFE and Bluetooth module on a custom designed PCB. Do I essentially need to purchase an EVM or I can go ahead with PCB design? Do I need to program ADS1293 and bluetooth module before it can be used?