At the moment i am suffering with a similar looking Problem.
I have a PCB board with two ADS1299 in daisy chain. It is wired to a data recorder. The SPI is terminated andsome ferrits are placed for electro magnetic compatibility.
Randomly are spikes arising. But always on all channels.
Can not figure out what the problem could be. It looks like happening randomly. About two times in a slot of 15minutes.
Has anybody an idea? The sinus is a test signal on one channel with 100µVpk-pk and 2Hz.