The AFE4403 datasheet says the following: "TI highly recommends that a single clock source be used to generate the clock required by the AFE as well as the clock needed by the microcontroller (MCU). If an independent clock source is used by the MCU, then any energy coupling into the AFE supply or ground or input pins can cause aliased spurious tones close to the heart rate being measured.”
Should I take this literally to mean that heart-rate measurement is adversely affected, but that SpO2 measurement is not, so that if we are only measuring SpO2 we don't need to have a common clock?