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ADS1292R Anti alias effect

Other Parts Discussed in Thread: ADS1292R

I am using ADS1292R and sampling at 500sps and with the register settings as per attached file. 

Our final schematic. 

Register settings are also attached.

Now I am facing a very strange problem. 

When I feed a sine wave it gets modulated as per attached image pic1.jpg

 Also when I connect ECG Simulator, the QRS waves slowly starts to decrease in amplitude then disappears and reappears after few seconds.

 I have switched off the respiration modulator and demodulator. Also I have checked the signal source and simulator for any faults and everything is proper.

 Is there something I am missing?  I feel this is due to some aliasing effect. Can you suggest some changes?