I want to use PGA308 as signal conditioner for the sigma-delta ADC of an MSP430F(G)4250. The sensor shall be a measuring bridge for pressure and it shall work in both directions. Excitation voltage of the measring bridge shall be 5V as well as the power supply for PGA308. I asssume it will be best to set Vref of PGA308 also to 5V for achieving a proper coarse offset compensation. A/D conversion of the PGA308 output signal will be done by the 16-bit sigma delta converter of the MSP430 which has a power supply of 3.6V. For measuring positive and negative pressure values, I have to use a virtual ground of about half the supply voltage of MSP430 (1.8V) and I have to shift zero voltage of PGA308 to this voltage. Unfortunately, the PGA308 has no input pin for such a virtual ground and it seems that its output amplifier is also related to GND instead to Vref/2 or to the Zero DAC voltage. Has anybody an idea how to measure positive and negative signals with this bridge amplifier?