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ADS124S06: ADS124S06 Digital Domain at PGA=64 and 128

Part Number: ADS124S06

Dear Sir,

May I ask what is advantage or disadvantage to use the digital domain? I probably do not understand how the digital amp (x2 oe x4) works with analog PGA (x32). 

If gain 64 and 128 will loose linearity of performance from below gain 32, I would like to know to avoid to use. I read electrical specification and found only gain error and analog supply current have a boundary difference at below gain 32 and above gain 64.

Best regards,

Masa