We have implemented a ISOUSB211 in a prototype design. We are using your reference designs for USB bus powered on the upstream side and 3V3 supply on the downstream side using internal 1V8 regulators. This design initially worked on 4/5 of our prototypes but after some unrelated rework only 2/5 functioned ever again. Probing the USB lines on the failing devices it looks like the USB fails in initialization with no chirp responses from upstream. On at least one of the non working devices the upstream side had a pulse on DP before the DP pullup. The downstream device is a FTDI FT4232. Do you know what could be causing this and/or ways to remedy this issue.