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For the input pins of unused channels, leaving them floating is not an issue but we recommend them to be connected to their default state to avoid any noise pick-up. e.g., for device ISO7761 (default HIGH, without suffix 'F') it is recommended to connect input pin to VCC through a pull-up resistor (typically 4.7kΩ). For ISO7761F (default LOW), it is recommended to connect the input pin to GND.
For the output pins of unused channels, it is best if they are left floating. Let me know if you have any questions on this, thanks.
