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TXB0104: TXB0104QRGYRQ1 - exposed thermal center pad

Part Number: TXB0104

For the Prat number TXB0104QRGYRQ1, The datasheet suggests that if this pin is used then connect it to the secondary ground or leave it open. 

My question is "what is this secondary ground?" 

is it referring to have multiple grounds? or common ground can be connected to ther exposed thermal center pad?

if the exposed thermal center pad is not intended to connect to the common ground then will it have any issues if connected?

  

Attached is my schamtics which I have followed. Please review the above schematics and let me know.