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SN74LVC8T245: max data rate

Part Number: SN74LVC8T245

Hi Team,

I can see the SN74LVC8T245 MAX data rate from our parametric search page, is it true this device can run up to 100Mhz at both A to B and B to A direction?

From my understand, max data rate can change according to loading and supply voltage, what is the general rule to support highest data rate?, in any specific voltage range for VccA  and VccB?

If SN74LVC8T245 has R/C loading like picture below, and VccA = 3.3V, VccB = 5V, customer wants to know the highest data rate this device support to from A to B direction. If we don't know, at least let us know, if 50MHz is no problem to support, thanks.

Regards,

Andrew