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TMS320F280039C: The pros and cons of control loop design

Part Number: TMS320F280039C

Tool/software:

Hi Champ,

For digital power delivery application, it is normally to see the running the control loop either designed with following PWM then triggering ISR or a fixed frequency (for example 50kHz) then executing once control loop. 

The question often asked by customer, what are the pros and cons of control loop designed in each way ? 

Would the expert explicitly explain the differences between them or on the basis of what to design in one of the way ? or is it purely depending on user's habit ?

Thanks and regards,

Johnny