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CCS/TMS320F28375D: Interrupts disabled on soft reset

Part Number: TMS320F28375D

Tool/software: Code Composer Studio

I'm working with a project that is exhibiting some odd behavior.  The code is very simple, basically just calls Device_init(), enables a few timer interrupts, calls InitFlash() and then spins in a while loop forever.  When I load this program via the CCS debugger, and watch counters in the timer ISR's they count up the first time I run the program.  However, when I reset the CPU in the CCS debugger via Run>Reset>CPU_Reset and then Run>Restart, the interrupt ISR's no longer get called (counters stay at zero).  Any ideas what could cause this behavior?