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getting simulation mode work with "real target application"

Hello

I prefer to test most of my code in the simulation mode. The simulation mode works OK with a bare main() { printf("hello world"); } application, where I need to add my functions one by one and test it to integrate with the "real target application".

Why is the simulation mode refusing to work with "real target application" which has hardware peripherals' code. For example, none of the example programs work in simulation mode.

Is there a list of corrective steps ( fresh build with cmd file changes / conditional compiling/...) that will make example programs work in simulation mode? 

Simulation mode is effective only when it works with "real target application" without much back and forth efforts. Is there a documentation on this?

Can someone help?

Thanks

Sayee