simulate program without using hardware

What do you want to simulate? Your complete system? What type of system? Or do you want to simulate any particular algorithm? Sorry, I was not able to understand your goal. I believe there is a simulator for the C28x core but I am almost sure there are no simulators for most of the peripherals. I personally believe it is better to use the actual hardware when available than simulation for system development. You may find the USB stick as a good way to develop code without investing too much time and effort on a full blown hardware system. Have you checked the various control cards TI offer on C2000?